![]() Although RCM is a useful diagnostic tool, it requires specialized training because the acquired images are grayscale, lack nuclear features, and are difficult to correlate with tissue pathology. ![]() Emerging noninvasive optical technologies such as reflectance confocal microscopy (RCM) can provide label-free, cellular-level resolution, in vivo images of skin without performing a biopsy. The process is cumbersome and time-consuming, often leading to unnecessary biopsies and scars. An invasive biopsy followed by histological staining is the benchmark for pathological diagnosis of skin tumors.
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